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Begutachtete Zeitschriftenartikel

2024

• Siebert, D., E. Glawischnig, M.-T. Wirth, M. Vannahme, Á. Salazar-Quirós, A. Weiske, E. Saydam, D. Möggenried, V. F. Wendisch, and B. Blombach. 2024. A genome-reduced Corynebacterium glutamicum derivative discloses a hidden pathway relevant for 1,2-propanediol production. Mircob. Cell Fact. 23:62.

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  Schulze, C., M. Hädrich, J. Borger, B. Rühmann, M. Döring, V. Sieber, F. Thoma, and B. Blombach. 2024. Investigation of exopolysaccharide formation and its impact on anaerobic succinate production with Vibrio natriegens. Microb. Biotechnol. 17:e14277.

2023

• Werner, F., L. S. Schwardmann, D. Siebert, C. Rückert-Reed, J. Kalinowski, M.-T. Wirth, K. Hofer, R. Takors, V. F. Wendisch, and B. Blombach. 2023. Metabolic engineering of Corynebacterium glutamicum for fatty alcohol production from glucose and wheat straw hydrolysate. Biotechnol. Biofuels Bioprod. 16 :116.
• Siebert, D., T. Busche, E. Saydam, J. Kalinowski, C. Rückert-Reed, and B. Blombach. 2023. Complete genome sequence of the carboxydotrophic knallgas bacterium Pseudomonas carboxydohydrogena strain DSM 1083. Microbiol. Resour. Announc. 12:e0127722.
•  Thoma, F., C. Appel, D. Russ, J. Huber, F. Werner, and B. Blombach. 2023. Improving growth properties of Corynebacterium glutamicum by implementing an iron-responsive protocatechuate biosynthesis. Microb. Biotechnol. 16:1041-1053.

2022

• Schmollack, M., F. Werner, J. Huber, D. Kiefer, M. Merkel, R. Hausmann, D. Siebert, and B. Blombach. 2022. Metabolic engineering of Corynebacterium glutamicum for acetate-based itaconic acid production. Biotechnol Biofuels Bioprod. 15:139.
• Bharti, R., D. Siebert, B. Blombach, and Dominik G. Grimm. 2022. Systematic analysis of the underlying genomic architecture for transcriptional-translational coupling in prokaryotes. NAR Genom. Bioinform. 4:lqac074.

• Merkel, M., D. Kiefer, M. Schmollack, B. Blombach, L. Lilge, M. Henkel, and R. Hausmann. 2022. Acetate-based production of itaconic acid with Corynebacterium glutamicum using an integrated pH-coupled feeding control. Bioresour. Technol. 351:126994.
• Blombach, B., A. Grünberger, F. Centler, N. Wierckx, and J. Schmid. 2022. Exploiting unconventional prokaryotic hosts for industrial biotechnology. Trends Biotechnol. 40:385-397.
• Siebert, D., B. J. Eikmanns, and B. Blombach. 2022. Exploiting aerobic carboxydotrophic bacteria for industrial biotechnology. Adv. Biochem. Eng. Biotechnol. 180:1-32.
• Thoma, F., C. Schulze, C. Gutierrez-Coto, M. Hädrich, J. Huber, C. Gunkel, R. Thoma, and B. Blombach. 2022. Metabolic engineering of Vibrio natriegens for anaerobic succinate production. Microb. Biotechnol. 15:1671-1684.

2021

• Siebert, D., J. Altenbuchner, and B. Blombach. 2021. A timed off-switch for dynamic control of gene expression in Corynebacterium glutamicum. Front. Bioeng. Biotechnol. 9:704681.
• Thoma, F., and B. Blombach. 2021. Metabolic engineering of Vibrio natriegens. Essays Biochem. 65:381–392.
• Ankenbauer, A., R. Nitschel, A. Teleki, T. Müller, L. Favilli, B. Blombach, and R. Takors. 2021. Micro-aerobic production of isobutanol with engineered Pseudomonas putida. Eng. Life Sci. 21:475-488.
• Kappelmann, J., B. Klein, M. Papenfuß, J. Lange, B. Blombach, R. Takors, W. Wiechert, T. Polen, and S. Noack. 2021. Comprehensive analysis of C. glutamicum anaplerotic deletion mutants under defined D-glucose conditions. Front. Bioeng. Biotechnol. 8:602936.

2020

• Feith, A., A. Schwentner, A. Teleki, L. Favilli, B. Blombach, and R. Takors. 2020. Streamlining the analysis of dynamic 13C-labeling patterns for the metabolic engineering of Corynebacterium glutamicum as L-histidine production host. Metabolites. 10:458.
• Müller, F., J. Rapp, A.-L. Hacker, A. Feith, R. Takors, and B. Blombach. 2020. CO₂/HCO₃^– accelerates iron reduction through phenolic compounds. mBio. 11:e00085-20.
• Nitschel, R., A. Ankenbauer, I. Welsch, N. T. Wirth, C. Massner, N. Ahmad, S. McColm, F. Borges, I. Fotheringham, R. Takors, and B. Blombach. 2020. Engineering Pseudomonas putida KT2440 for the production of isobutanol. Eng. Life Sci. 20:148-159.
• Lindner, S. N., S. Aslan, A. Müller, E. Hoffart, P. Behrens, C. Edlich‐Muth, B. Blombach, and Arren Bar‐Even. 2020. A synthetic glycerol assimilation pathway demonstrates biochemical constraints of cellular metabolism. FEBS J. 287:160-172.

2019

• Grenz S., P. T. Baumann, C. Rückert, B. A. Nebel, D. Siebert, A. Schwentner, B. J. Eikmanns, B. Hauer, J. Kalinowski, R. Takors, and B. Blombach. 2019. Exploiting Hydrogenophaga pseudoflava for aerobic syngas-based production of chemicals. Metab. Eng. 55:220-230.
• Graf, M., T. Haas, F. Müller, J. Harm-Bekbenbetova, A. Freund, A. Nieß, M. Persicke, J. Kalinowski, B. Blombach, and R. Takors. 2019. Continuous adaptive evolution of a fast-growing Corynebacterium glutamicum strain independent of protocatechuate. Front. Microbiol. 10:1648.
• Pfeifer, E., S. Michniewski, C. Gätgens, E. Münch, F. Müller, T. Polen, A. M., B. Blombach, and J. Frunzke. 2019. Generation of a prophage-free variant of the fast-growing bacterium Vibrio natriegens. Appl. Environ. Microbiol. 85:e00853-19.
• Haas, T., M. Graf, A. Nieß, T. Busche, J. Kalinowski, B. Blombach, and R. Takors. 2019. Identifying the growth modulon of Corynebacterium glutamicum. Front. Microbiol. 10:974.
• Schwentner, A., A. Feith, E. Münch, J. Stiefelmaier, I. Lauer, L. Favilli, C. Massner, J. Öhrlein, B. Grund, A. Hüser, R. Takors and B. Blombach. 2019. Modular systems metabolic engineering enables balancing of relevant pathways for L-histidine production with Corynebacterium glutamicum. Biotechnol. Biofuels. 12:65.

2018

• Schleicher, L., V. Muras, B. Claußen, J. Pfannstiel, B. Blombach, P. Dibrov, G. Fritz, and J. Steuber. 2018. Vibrio natriegens as host for expression of multisubunit membrane protein complexes. Front. Microbiol. 9:2537.
• Graf, M., J. Zieringer, T. Haas, A. Nieß, B. Blombach, and R. Takors. 2018. Physiological response of Corynebacterium glutamicum to increasingly nutrient-rich growth conditions. Front. Microbiol. 9 :2058.
• Lange, J., E. Münch, J. Müller, T. Busche, J. Kalinowski, R. Takors, and B. Blombach. 2018. Deciphering the adaptation of Corynebacterium glutamicum in transition from aerobiosis via microaerobiosis to anaerobiosis. Genes. 9:297.
• Failmezger, J., S. Scholz, B. Blombach, and M. Siemann-Herzberg. 2018. Cell-free protein synthesis from fast-growing Vibrio natriegens. Front. Microbiol. 9:1146.
• Shah, A., B. Blombach, R. Gauttam, and B. J. Eikmanns. 2018. The RamA regulon: complex regulatory interactions in relation to central metabolism in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 102:5901-5910.
• Takors, R., M. Kopf, J. Mampel, W. Bluemke, B. Blombach, B. Eikmanns, FR Bengelsdorf, D. Weuster-Botz, and P. Dürre. 2018. Using gas mixtures of CO, CO₂ and H₂ as microbial substrates: the do’s and don’ts of successful technology transfer from laboratory to production scale. Microb. Biotechnol. 11:606-625.
• Schwentner, A., A. Feith, E. Münch, T. Busche, C. Rückert, J. Kalinowski, R. Takors, and B. Blombach. 2018. Metabolic engineering to guide evolution – creating a novel mode for L-valine production with Corynebacterium glutamicum. Metab. Eng. 47:31-41.
• Lange, J., F. Müller, R. Takors, and B. Blombach. 2018. Harnessing novel chromosomal integration loci to utilize an organosolv-derived hemicellulose fraction for isobutanol production with engineered Corynebacterium glutamicum. Microb. Biotechnol. 11:257-263.

2017

• Lange, J., F. Müller, K. Bernecker, N. Dahmen, R. Takors, and B. Blombach. 2017. Valorization of pyrolysis water – a biorefinery side stream – for 1,2-propanediol production with engineered Corynebacterium glutamicum. Biotechnol. Biofuels. 10:277.
• Hoffart, E., S. Grenz, J. Lange, R. Nitschel, F. Müller, A. Schwentner, A. Feith, M. Lenfers-Lücker, R. Takors, and B. Blombach. 2017. High substrate uptake rates empower Vibrio natriegens as production host for industrial biotechnology. Appl. Environ. Microbiol. 83:e01614-17.

2016

• Radoš, D., D. L. Turner, T. Catarino, E. Hoffart, A. R. Neves, B. J. Eikmanns, B. Blombach, and H. Santos. 2016. Stereospecificity of Corynebacterium glutamicum 2,3-butanediol dehydrogenase and implications for the stereochemical purity of bioproduced 2,3-butanediol. Appl. Microbiol. Biotechnol. 100:10573-10583.
• Lange, J., R. Takors, and B. Blombach. 2016. Zero-growth bioprocesses – A challenge for microbial production strains and bioprocess engineering. Eng. Life Sci. 17:27-35.
• Zetzmann, M., A. Sánchez-Kopper, M. S. Waidmann, B. Blombach, and C. U. Riedel. 2016. Identification of the agr peptide of Listeria monocytogenes. Front. Microbiol. 7:989.

2015

• Radoš, D., A. L. Carvalho, S. Wieschalka, A. R. Neves, B. Blombach, B. J. Eikmanns, and H. Santos. 2015. Engineering Corynebacterium glutamicum for the production of 2,3‑butanediol. Microb. Cell Fact. 14:171.
• Blombach, B., and R. Takors. 2015. CO₂ – intrinsic product, essential substrate and regulatory trigger of microbial and mammalian production processes. Front. Bioeng. Biotechnol. 3:108.

2014

• Buchholz, J., M. Graf, A. Freund, T. Busche, J. Kalinowski, B. Blombach, and R. Takors. 2014. CO₂/HCO₃− perturbations of simulated large scale gradients in a scale-down device cause fast transcriptional responses in Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 98:8563-8572.
• Buchholz, J., M. Graf, B. Blombach, and R. Takors. 2014. Improving the carbon balance of fermentations by total carbon analysis. Biochem. Eng. J. 90:162-169.
• Oldiges, M., B. J. Eikmanns, and B. Blombach. 2014. Application of metabolic engineering for the biotechnological production of L-valine. Appl. Microbiol. Biotechnol. 98:5859-5870.
• Radoš, D., D. L. Turner, L. L. Fonseca, A. L. Carvalho, B. Blombach, B. J. Eikmanns, A. R. Neves, and H. Santos. 2014. The effect of CO₂ on anaerobic succinate production by Corynebacterium glutamicum: carbon flux analysis by ¹³C-NMR. Appl. Environ. Microbiol. 80:3015-3024.
• Eikmanns, B. J., and B. Blombach. 2014. The pyruvate dehydrogenase complex of Corynebacterium glutamicum: An attractive target for metabolic engineering. J. Biotechnol. 192:339-345.
• Mustafi, N., A. Grünberger, R. Mahr, S. Helfrich, K. Nöh, B. Blombach, D. Kohlheyer, and J. Frunzke. 2014. Application of a genetically encoded biosensor for live cell imaging of L-valine production in pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum strains. PloS ONE. 9:e85731.

2013

• Blombach, B., J. Buchholz, T. Busche, J. Kalinowski, and R. Takors. 2013. Impact of different CO₂/HCO₃– levels on metabolism and regulation in Corynebacterium glutamicum. J. Biotechnol. 168:331-340.
• Buchholz, J., A. Schwentner, B. Brunnenkan, C. Gabris, S. Grimm, R. Gerstmeir, R. Takors, B. J. Eikmanns, and B. Blombach. 2013. Platform Engineering of Corynebacterium glutamicum with reduced pyruvate dehydrogenase complex activity for improved production of L-lysine, L-valine, and 2-ketoisovalerate. Appl. Environ. Microbiol. 79:5566-5575.

2012

• Wieschalka, S., B. Blombach, M. Bott, and B. J. Eikmanns. 2012. Bio-based production of organic acids with Corynebacterium glutamicum. Microb. Biotechnol. 6:87-102.
• Wieschalka, S., B. Blombach, and B. J. Eikmanns. 2012. Engineering Corynebacterium glutamicum for the production of pyruvate. Appl. Microbiol. Biotechnol. 94:449-459.

2011

• Blombach, B., T. Riester, S. Wieschalka, C. Ziert, J-W Youn, V. F. Wendisch, and B. J. Eikmanns. 2011. Corynebacterium glutamicum tailored for efficient isobutanol production. Appl. Environ. Microbiol. 77:3300–3310.
• Blombach, B., and B. J. Eikmanns. 2011. Current knowledge on isobutanol production with Escherichia coli, Bacillus subtilis and Corynebacterium glutamicum. Bioeng. Bugs. 2:1-5.
• Bartek T., B. Blombach, S. Lang, B. J. Eikmanns, W. Wiechert, M. Oldiges, K. Nöh, and S. Noack. 2011. Comparative ¹³C metabolic flux analysis of pyruvate dehydrogenase complex-deficient L-valine-producing Corynebacterium glutamicum. Appl. Environ. Microbiol. 77:6644–6652.

2010

• Blombach, B., and G. M. Seibold. 2010. Carbohydrate metabolism in Corynebacterium glutamicum and applications for the metabolic engineering of L-lysine production strains. Appl. Microbiol. Biotechnol. 86:1313-22.
• Krause F. S., B. Blombach, and B. J. Eikmanns. 2010. Metabolic engineering of Corynebacterium glutamicum for 2-ketoisovalerate production. Appl. Environ. Microbiol. 76:8053–8061.
• Bartek T., C. Rudolf, U. Kerßen, B. Klein, B. Blombach, S. Lang, B. J. Eikmanns, and M. Oldiges. 2010. Studies on substrate utilisation in L-valine-producing Corynebacterium glutamicum strains deficient in pyruvate dehydrogenase complex. Bioprocess. Biosyst. Eng. 33:873-883.
• Bartek T., B. Blombach, E. Zönnchen, P. Makus, S. Lang, B. J. Eikmanns, and M. Oldiges. 2010. Importance of NADPH supply for improved L-valine formation in Corynebacterium glutamicum. Biotechnol. Prog. 26:361-71.
• Krause F., A. Henrich, B. Blombach, R. Krämer, B. J. Eikmanns, and G. M. Seibold. 2010. Maltose improves glucose utilization in Corynebacterium glutamicum: Application for the improvement of L-valine productivity. Appl. Environ. Microbiol. 76:370-374.

2009

• Blombach, B., A. Arndt, M. Auchter, and B. J. Eikmanns. 2009. L-Valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR. Appl. Environ. Microbiol. 75:1197-1200.
• Blombach, B., A. Cramer, B. J. Eikmanns, and M. E. Schreiner. 2009. RamB is an activator of the pyruvate dehydrogenase complex subunit E1p gene in Corynebacterium glutamicum. J. Mol. Microbiol. Biotechnol. 16:236-239.
• Blombach, B., S. Hans, B. Bathe, and B. J. Eikmanns. 2009. Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum. Appl. Environ. Microbiol. 75:419-427.

2008

• Blombach, B., M. E. Schreiner, T. Bartek, M. Oldiges, and B. J. Eikmanns. 2008. Corynebacterium glutamicum tailored for high-yield L-valine production. Appl. Microbiol. Biotechnol. 79:471-479.

2007

• Blombach, B., M. E. Schreiner, J. Holátko, T. Bartek, M. Oldiges, and B. J. Eikmanns. 2007. L-Valine production with pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum. Appl. Environ. Microbiol. 73:2079-2084.
• Blombach, B., M. E. Schreiner, M. Moch, M. Oldiges, and B. J. Eikmanns. 2007. Effect of pyruvate dehydrogenase complex deficiency on L-lysine production with Corynebacterium glutamicum. Appl. Microbiol. Biotechnol. 76:615-623.

Nicht begutachtete Zeitschriftenartikel

• Siebert, D., and B. Blombach. 2022. Carboxydotrophe Knallgasbakterien zur aeroben Nutzung von CO, CO₂ und H₂. BIOspektrum. 28:553-555.

• Müller, F., and B. Blombach. 2019. Vibrio natriegens – eine neue Plattform für die Biotechnologie? BIOspektrum. 25:570-571.

• Blombach B., K. Castiglione, T. Haarmann, and J. Schmid. 2015. Mikrobielle Stammentwicklung: Trends in der Genomeditierung für die industrielle Biotechnologie. BIOspektrum. 21:788-790.

• Blombach B., and B. J Eikmanns. 2014. Corynebacterium glutamicum als Produzent von Pyruvat-abgeleiteten Produkten. BIOspektrum. 20:696-699.

Buchkapitel

• Bioprocessing of renewable resources to commodity bioproducts. 2014. V. S. Bisaria and A. Kondo (Ed.). Chapter 12: Isobutanol, B. J. Eikmanns and B. Blombach.

Patente

• Bathe B., B. Blombach, B. J. Eikmanns, V. Engels, G. Thierbach, and V. F. Wendisch. 2012. Process for the fermentative preparation of organic chemical compounds using coryneform bacteria in which the sugR gene is present in attenuated form. US 08,133,714; US 08,592,177.