Curriculum Vitae

• Since 2024: Research Associate/Postdoc at the Professorship Microbial Biotechnology, Technical University of Munich (TUM), Campus Straubing for Biotechnology and Sustainability.
• 2023: Research Associate/Postdoc at the University of Bern in the field of enzyme immobilization
• 2017 – 2022: Doctorate at the University of Regensburg in the department of Prof. Dr. Reinhard Sterner. Thesis: “Reconstruction of the Emergence of New Enzyme Functions by Protein Engineering: Examples From Secondary and Xenobiotic Metabolism”
• 2014-2017: M.Sc. in Biochemistry at the University of Regensburg. Thesis: “Attempts to establish a secondary metabolic enzyme activity on the protein scaffold of a primary metabolic enzyme”
• 2011-2014: B.Sc. in Biochemistry at the University of Regensburg. Thesis: “Experimentelle Validierung von Korrelationsanalysen am Beispiel des dimeren Enzymkomplexes PabA:PabB aus E.coli” (“Experimental validation of correlation analyses in the dimeric enzyme complex PabA:PabB from E. coli“)

Publications

• 2023

  • Busch, M., Drexler, L., Mahato, D. R., Hiefinger, C., Osuna, S., & Sterner, R. (2023). Retracing the Rapid Evolution of an Herbicide-Degrading Enzyme by Protein Engineering. ACS Catalysis, 15558–15571. doi:10.1021/acscatal.3c04010
  • Busch, M., Rajendran, C., & Sterner, R. (2023). Structural and Functional Characterization of the Ureidoacrylate Amidohydrolase RutB from Escherichia coli. Biochemistry, 62(3), 863–872. doi:10.1021/acs.biochem.2c00640

   2017

  • Plach, M. G., Semmelmann, F., Busch, F., Busch, M., Heizinger, L., Wysocki, V. H., . . . Sterner, R. (2017). Evolutionary diversification of protein-protein interactions by interface add-ons. Proceedings of the National Academy of Sciences of the United States of America, 114(40), E8333–E8342. doi:10.1073/pnas.1707335114

   2014

  • Janda, J.-O., Popal, A., Bauer, J., Busch, M., Klocke, M., Spitzer, W., . . . Merkl, R. (2014). H2rs: Deducing evolutionary and functionally important residue positions by means of an entropy and similarity based analysis of multiple sequence alignments. BMC Bioinformatics, 15(1), 118. doi:10.1186/1471-2105-15-118

  2012

  • Janda, J.-O., Busch, M., Kuck, F., Porfenenko, M., & Merkl, R. (2012). CLIPS-1D: Analysis of multiple sequence alignments to deduce for residue-positions a role in catalysis, ligand-binding, or protein structure. BMC Bioinformatics, 13(1), 55. doi:10.1186/ 1471-2105-13-55